The Science Behind the Tools

Evidence-informed wellness starts with understanding the research. Explore the peer-reviewed science behind peptide bioregulators, cellular aging, neuroplasticity, and longevity.

40+
Years of Research
200+
Clinical Studies
15M+
Patients Treated
100+
Patents Worldwide
Pioneer in Peptide Research

Professor Vladimir Khavinson

Professor Vladimir Khavinson is a world-renowned gerontologist and the pioneer of peptide bioregulator research. As the President of the European Academy of Gerontology and Geriatrics, he has dedicated over 40 years to studying the effects of short peptides on aging and disease.

His groundbreaking research has resulted in the development of numerous peptide bioregulators that are now used worldwide to support healthy aging and organ function.

200+ Publications 15 Monographs 100+ Patents
Research Laboratory
Next-Generation Technology

Prime Peptide® IPH Technology

Innovative Peptide Health (IPH) technology represents the latest advancement in peptide bioregulation, developed by the St. Petersburg Institute of Bioregulation and Gerontology.

IPH REG Complex

An innovative natural bioregulator with powerful cellular protection properties:

  • Oncoprotective properties for cellular defense
  • Regenerative capabilities for tissue repair
  • Antioxidant protection against oxidative stress
  • Supports natural antitumor defenses
IPH EP Complex

Advanced peptide complex with pronounced anti-aging effects:

  • Promotes comprehensive cellular protection
  • Restores cellular functionality and vitality
  • Modulates expression of tumor suppressor proteins
  • Clinically validated for effectiveness
How IPH Technology Works
1

Cellular Regulation

IPH peptides act as natural bioregulators at the cellular level

2

Gene Expression

Modulates expression of key proteins for cellular health

3

Oxidative Protection

Protects cells from oxidative stress and damage

4

Tissue Regeneration

Stimulates natural regeneration mechanisms

5

Anti-Aging

Targets key aging mechanisms for comprehensive support

"Modern research in gerontology shows that regulatory processes at the cellular and tissue levels determine the quality and longevity of our lives. Peptides serve as a natural tool for managing these processes. Prime Peptide® products are innovative complexes developed in line with the latest advances in longevity science."

Foundational Science

Understanding Peptide Bioregulators

Peptides are the body's natural information carriers — short chains of amino acids that signal cells to maintain, repair, and regulate their own function. As we age, peptide levels decline significantly, contributing to the gradual loss of organ function and resilience.

What Are Peptides?

A peptide is a molecule consisting of two or more amino acids linked together with a peptide bond. With a size of up to 1 nanometer, peptides are part of the nanoworld. Conventionally, a peptide molecule consists of under 100 amino acids, while a protein molecule contains over 100. Peptides can be derived from plants or animals as well as artificially synthesized.

In the body, peptides carry information, transferring biological signals from one cell to another to ensure proper functioning. When cells work correctly, the whole body functions optimally. Natural peptides are organic substances that regulate cellular condition, enabling the body to heal itself through cellular-level normalization.

Cellular Communication

Life exists because of two kinds of molecules: peptides that carry information and DNA that stores genetic information. When peptides enter the body, they immediately begin their work, giving new life to cells by replacing old, damaged cells with new ones.

Peptides can increase cell lifetime by 30-40%, launching an active recovery process throughout the body.

Gene Regulation

Peptide bioregulators have a unique capability to restore protein synthesis in the body that decreases due to illness or aging. This restoration increases adaptation potential and recovery of functional activity.

Peptides regulate gene activity, decreasing the activity of "bad" genes while activating "good" genes, thereby stimulating the production of beneficial proteins.

Age-Related Peptide Decline
10x

The amount of peptides in a 55-year-old is 10 times less than in a 20-year-old

90

Natural aging theoretically starts after age 90 — what we see now is premature aging

40+

Systematic use of peptide bioregulators is advisable starting from age 40

Protein synthesis smoothly reduces with age, leading to body dysfunction. Elderly people experience longer lasting sicknesses and recovery periods due to dramatically reduced peptide levels.

The Essential Role of Proteins

Proteins are the construction material for any living organism. Each protein has its own unique structure and performs strictly defined functions in the body:

Protein hormones

Involved in all life processes including growth and reproduction

Contractile proteins

Actin and myosin enable all muscle movement

Protein enzymes

Maintain all chemical processes: respiration, digestion, metabolism

Hemoglobin

Carries oxygen to cells and removes carbon dioxide

Immunoglobulins

Antibodies that protect from pathogens, viruses, and bacteria

Fibrinogen

Responsible for blood clotting in wounds

Benefits of Peptide Bioregulators

Anti-Aging Effects

Actively prevent aging processes, launch recovery mechanisms, and increase cellular resistance to toxins and harmful factors.

Immediate Action

Unlike supplements that may take time to show effects, peptides begin working immediately upon entering the body.

Tissue-Specific Action

Different peptide bioregulators target specific organs and tissues, providing targeted support where needed.

Scientific Foundation: The Institute of Gerontology and Bio-Regulation led by Prof. V.Kh. Khavinson developed a comprehensive program after 20 years of research focusing on prevention of age-related problems, decreased mortality, and increased working period.

Research Library

Explore peer-reviewed research on peptide bioregulators, NAD+ science, autophagy, and longevity interventions.

Anti-Aging
Peptide Bioregulators: A New Class of Geroprotectors

Khavinson V, Linkova N, Dyatlova A, Kuznik B, Umnov RCurrent Aging Science (2020)

This review summarizes data on the geroprotective properties of short peptides. Peptide bioregulators have been shown to regulate gene expression, restore protein synthesis, and slow down aging processes in various organ systems.

Gene Expression
Short Peptides Regulate Gene Expression, Protein Synthesis and Enhance Life Span

Khavinson VK, Linkova NS, Tarnovskaya SIAdvances in Gerontology (2021)

The study demonstrates that short peptides can penetrate into the cell nucleus and regulate gene expression. This mechanism underlies the geroprotective effects of peptide bioregulators.

Clinical Trial
Epithalamin and Thymalin: Effects on Aging and Cancer Prevention

Anisimov VN, Khavinson VKExperimental Gerontology (2003)

Long-term clinical study showing that epithalamin and thymalin treatment in elderly patients resulted in decreased mortality, improved immune function, and reduced cancer incidence over a 6-year follow-up period.

NAD+ Research
NAD+ and Sirtuins in Aging and Disease

Imai S, Guarente LTrends in Cell Biology (2018)

Comprehensive review of NAD+ metabolism and its role in aging. NAD+ decline is a hallmark of aging, and NAD+ supplementation has shown promise in extending healthspan in various model organisms.

Autophagy
Spermidine Induces Autophagy and Extends Lifespan

Eisenberg T, Knauer H, Schauer A, et al.Nature Cell Biology (2016)

This landmark study demonstrates that spermidine supplementation triggers autophagy and extends lifespan in yeast, flies, worms, and human cells. The findings support spermidine as a promising longevity intervention.

Mitochondria
Coenzyme Q10 and Mitochondrial Function in Aging

Hernández-Camacho JD, Bernier M, López-Lluch G, Navas PFrontiers in Physiology (2018)

Review of CoQ10's essential role in mitochondrial energy production and its decline with age. Supplementation has shown benefits for cardiovascular health, energy levels, and cellular protection.

Circadian Rhythm
Pineal Peptides and Melatonin: Circadian Rhythm Regulation

Khavinson VK, Goncharova ND, Lapin BANeuroendocrinology Letters (2001)

Study demonstrating that pineal peptides (Epithalamin/Endoluten) can restore melatonin production and normalize circadian rhythms in aging primates, with implications for human aging.

Immune System
Thymus Peptides and Immune System Restoration

Khavinson VK, Morozov VGMechanisms of Ageing and Development (2003)

Clinical evidence showing that thymus peptides (Thymalin/Vladonix) can restore immune function in elderly patients, reducing infection rates and improving overall health outcomes.

Sirtuins
Resveratrol and Sirtuin Activation for Longevity

Baur JA, Sinclair DANature Reviews Drug Discovery (2006)

Comprehensive review of resveratrol's mechanisms of action, including sirtuin activation, and its potential as a calorie restriction mimetic for extending healthspan.

Joint Health
Cartilage Peptides for Joint Health and Regeneration

Khavinson VK, Ryzhak GA, Grigoriev EIBulletin of Experimental Biology and Medicine (2017)

Study showing that cartilage-derived peptides (Cartalax) can stimulate chondrocyte proliferation and matrix synthesis, supporting joint health and potentially slowing osteoarthritis progression.

Cardiovascular
Cardiovascular Peptides: Heart and Vessel Protection

Khavinson VK, Linkova NS, Kvetnoy IMAdvances in Gerontology (2019)

Review of cardiovascular peptide bioregulators including Chelohart and Ventfort, demonstrating their ability to support heart muscle function and blood vessel health in aging.

Cognitive Health
Brain Peptides and Cognitive Function in Aging

Khavinson VK, Malinin VV, Grigoriev EIPeptides (2014)

Study demonstrating that brain-derived peptides can improve cognitive function, memory, and neuroprotection in aging models, with potential applications for age-related cognitive decline.

How Peptide Bioregulators Work

Understanding the science behind peptide bioregulation

1

Cellular Uptake

Short peptides (2-4 amino acids) are absorbed and transported into cells, where they can reach the nucleus.

2

Gene Regulation

Peptides interact with DNA and histones to regulate gene expression, activating genes responsible for protein synthesis.

3

Tissue Restoration

Increased protein synthesis leads to improved tissue function, cellular regeneration, and organ health.